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Many organisms ranging from bacteria to humans display circadian (≅24 h) rhythms in a wide variety of biochemical, physiological, and behavioral phenomena (for a review, see reference 19).
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Nevertheless, because mammalian Clock mRNA is constitutively expressed, our findings are a further example of striking differences in the regulation of putative circadian clock orthologs in different species. The isolation of a Drosophila homolog of Clock together with the recent discovery of mammalian homologs of per indicate that there is high structural conservation in the integral components underlying circadian oscillators in Drosophila and mammals. Finally, the temporal regulation of dClock expression is quickly perturbed by shifts in light-dark cycles, indicating that this molecular rhythm is closely connected to the photic entrainment pathway. Furthermore, dClock RNA cycling is abolished and the levels are at trough values in the absence of either PER or TIM, suggesting that these two proteins can function as transcriptional activators, a possibility which is in stark contrast to their previously characterized role in transcriptional autoinhibition. Cell 93:791–804, 1998, and Darlington et al., Science 280:1599–1603, 1998.) Transcripts from this putative Clock ortholog (designated dClock) undergo daily rhythms in abundance that are antiphase to the cycling observed for the RNA products from the Drosophila melanogaster circadian clock genes period ( per) and timeless ( tim).
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(Similar findings were recently described by Allada et al. Here we report the characterization of a novel Drosophila bHLH-PAS protein that is highly homologous to mammalian CLOCK. A light sensor will switch the clock to an invert mode: the figures are white in the dark time of day and black at daytime.The Clock gene plays an essential role in the manifestation of circadian rhythms (≅24 h) in mice and is a member of the basic helix-loop-helix (bHLH) PER-ARNT-SIM (PAS) superfamily of transcription factors. Each figure has self-contained power supply and independent control, it can be fixed to any surface autonomously. “Digital clock: only figures, no case, only the necessary – only accurate time. More durable than wood or glass and lighter than metal, the unique hybrid polycarbonate surface is sustainable as well as durable by design. Touch-sensitive panels let you change the time without moving them. It might not keep time at the atomic level, but its energy-efficient power system should last a long time – and cheap materials will hopefully keep the price down as well when the time comes you can buy one. The aesthetic of the idea are recognizably patterned after the familiar giant-sized, billboard style numerals we are used to seeing on everything from small nightstand alarm clocks to huge sports scoring boards.
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Softly-rounded rectangular corners make these child-friendly and relatively easy to install as well – that is, once these prototypes from Kibardin Design find a manufacturer and go on sale for real. Each over-sized digital number is independently attached to a surface (and completely wire-free) so you can place and space them as you wish on any interior wall, a contemporary decorative touch that also tells time.